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KMID : 0370019920060000047
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Chung-Ang Journal of Pharmacal Sciences
1992 Volume.6 No. 0 p.47 ~ p.55
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Inhibitory Action of Diphenl-dimethyl-dicarboxylate on Fe(Ⅱ)-induced Lipid Peroxidation
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Abstract
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Inhibitory effect of diphenyl-dimethyl-dicarboxylate(PMC) on ferrous ion-dependent lipid peroxidation in rat liver microsomes was studied to elucidate the chelating action for iron and the scavenging action for oxygen radicals produced during oxidation of iron. PMC was observed as a significant inhibitor of iron iondependent lipid peroxidation system. Lipid peroxidation by ascorbate in the presence of Fe^2+ was inhibited by PMC. PMC inhibited oxi-dation of Fe^2+ and it showed a significant initial chelating effect. PMC effectively inhibited lipid peroxidation by H_2O_2 and decomposed H_2O_2 OH·production in the presence of Fe^2+ was inhibited by PMC. Inhibitory effect of PMC on the peroxidative action of Fe^2+ in the presence or absence of ascorbate may be scavenging action on reactive oxygen species and chelating action on iron.
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